We propose to better characterise the repetitive intratracheal BLM-induced fibrosis mice model using high resolutive imaging.
Read MoreLung Fibrogenesis
Our aim is to contribute to the understanding of the pathological process that regulate the initiation, progression and exacerbation of lung fibrosis at the tissular, cellular and molecular level to discover new relevant biomarkers and targeted therapies.
Lung Fibrosis
Idiopathic pulmonary fibrosis is a chronic and life-threatening interstitial lung disease of unknown origin, characterized by lung tissue scarring, destruction of alveolar structures and disrupted gas exchange leadinf to respiratory failure ans death. IPF’s natural history is heterogeneous, and its progression unpredictable. Currently, no effective treatment is available, the existing antifibrotic drugs are only able to slow the disease progression.
Our goal is to improved the comprehension of the pathogenetic mechanisms through the développement of appropriate in vitro models and an in-depth characterisation of the signaling pathways implicated in intercellular communication during the fibrotic process.
Research axis
Developpement of in vitro models for the study of airway cellular interactions
The aim is to propose a new invitro complex co-culture to study the intercellular communication involved in the pro-fibrotic process.
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Exploration of Exhaled Breath condensate fluid
To explore the exhaled breast condensate of patients as an original human biological fluid reflecting the airway compartment to monitor disease progression.
Read MoreImplication of ER stress and UPR actors on the fibrotic process
ER stress implication in the fibrotic process has been largely documented in many organs. We propose to specially document the implication of […]
Read MorePeople involved
CEA Researcher
Emilie Boncoeur
CEA Engineer
Florence Combes
Inserm Engineer
Annie Adrait
CEA Technician
Marie Courçon
CEA Researcher
Michel Jaquinod
Inserm Technician
Sandrine Miesch-Frémy
CEA L3 Student
Maëva Magniat
CEA PHD
Simon Paul
Publications
- Maakoul Z, Yegen CH, Marchant D, Bernaudin JF, Planès C, Voituron N, Boncoeur E. Interruption of intermittent hypoxia attenuates the severity of pulmonary fibrosis in male mice. Physiol Rep. 2025 May;13(10):e70335. doi: 10.14814/phy2.70335. PMID: 40405523; PMCID: PMC12098967.
- Delbrel E, Voituron N, Boncoeur E. HIF and ER stress are involved in TGFβ1-mediated wound closure of alveolar epithelial cells. Exp Lung Res. 2023;49(1):63-71. doi: 10.1080/01902148.2023.2183996. Epub 2023 Mar 22. PMID: 36947400.
- Yegen CH, Haine L, Da Costa Ferreira K, Marchant D, Bernaudin JF, Planès C, Voituron N, Boncoeur E. A New Model of Acute Exacerbation of Experimental Pulmonary Fibrosis in Mice. Cells. 2022 Oct 26;11(21):3379. doi: 10.3390/cells11213379. PMID: 36359778; PMCID: PMC9654438.
- Haine L, Bravais J, Yegen CH, Bernaudin JF, Marchant D, Planès C, Voituron N, Boncoeur E. Sleep Apnea in Idiopathic Pulmonary Fibrosis: A Molecular Investigation in an Experimental Model of Fibrosis and Intermittent Hypoxia. Life (Basel). 2021 Sep 15;11(9):973. doi: 10.3390/life11090973. PMID: 34575121; PMCID: PMC8466672.
- Lacombe M, Marie-Desvergne C, Combes F, Kraut A, Bruley C, Vandenbrouck Y, Chamel Mossuz V, Couté Y, Brun V. Proteomic characterization of human exhaled breath condensate. J Breath Res. 2018 Feb 20;12(2):021001. doi: 10.1088/1752-7163/aa9e71. PMID: 29189203.
