Identifying HBc nuclear regulatory functions Despite the existence of a preventive vaccine, chronic infections with Hepatitis B virus (HBV) remain a major health problem worldwide, and represent the first cause of liver cancer. Current clinically accepted antivirals treatments generally lead to a significant reduction of viremia in the blood of patients. However, the liver viral […]
Understanding antibiotic resistance of Francisella ssp Francisella tularensis is the causative agent in tularemia for which the high prevalence of treatment failure and relapse is a major concern. Using MS-based proteomics, we explore the proteomes of different Francisella strains to identify proteins that may contribute to reduced antibiotic susceptibility. Collaborators Patricia Renesto, Experimental Recombinant Therapy […]
Elucidating strategies developed by Toxoplasma gondii to orchestrate immune evasion and lifelong persistence in hosts Identification of parasite factors able to subvert activities of the host, principally focusing on nuclear proteins such as transcription factors, and modulation of the epigenetic status of target genes, leading to reshape the host genetic program. We aim to study […]
Immunoassays are used for decades in clinical laboratories to quantify proteins in blood samples. However, MS-based proteomics analysis has recently appeared as a promising option to assess panels of protein biomarkers and provide protein profiles useful for health state monitoring. Nevertheless, the translation of MS-based proteomics into the clinics is hampered by the complexity, the […]
Modelling Mixotrophy in the extremophile alga Galdieria sulphuraria Galdieria sulphuraria is a photosynthetic microalga isolated in volcanic zones. This acidophilic and thermophilic alga is characterized by a high metabolic flexibility as well as by a high biomass productivity. G sulphuraria is able to grow in phototrophic and heterotrophy regimes as well as in mixotrophic conditions. […]
Functional and molecular characterization of giant viruses The recent discovery in various spots around the world of novel giant viruses largely made of proteins with no homologs in other species raised many questions about their origin but also about the way they can manipulate the standard biochemical building blocks of the living world using vastly […]
