Identifying HBc nuclear regulatory functions Despite the existence of a preventive vaccine, chronic infections with Hepatitis B virus (HBV) remain a major health problem worldwide, and represent the first cause...Read More
Based on its core facility, EDyP has contributed to many scientific projects through the development, implementation and provision of tailored proteomics approaches to characterize specific biological systems in the frame of granted projects. This required a constant optimization of the applied proteomic pipeline, from biochemistry (e.g. fractionation of highly complex samples, enrichment of peptides bearing specific post-translational modifications) and analytical science (optimization of LC gradients and MS acquisition strategies) to data analysis (implementation of dedicated computational and statistical workflows allowing the relative or absolute quantification of proteins).
Some granted projects
Understanding antibiotic resistance of Francisella ssp Francisella tularensis is the causative agent in tularemia for which the high prevalence of treatment failure and relapse is a major concern. Using MS-based...Read More
Elucidating strategies developed by Toxoplasma gondii to orchestrate immune evasion and lifelong persistence in hosts Identification of parasite factors able to subvert activities of the host, principally focusing on nuclear...Read More
Functional and molecular characterization of giant viruses The recent discovery in various spots around the world of novel giant viruses largely made of proteins with no homologs in other species...Read More